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Representative tracings (A and B) and grouped data (C) illustrating the sympathoexcitatory responses to bilateral PVN microinjections of PGE2 (A) and misoprostol (B). Both drugs produced significant increases of RSNA, HR and BP, or MBP. Bilateral PVN pretreatment with the EP3 receptor antagonist L-798106 (2 nmol) prevented the PGE2-induced responses. Arrows indicate time of agonist injections. n, Number of interventions. *P < 0.05 vs. Veh; †P < 0.05 vs. PGE2.
