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Numerical model simulations of dog ventricular myocyte APs (A and B) and simultaneous INaL dynamics (C and D) from normal and failing hearts (normal vs. HF, respectively) in control and in response to SCN1B or SCN2B gene silencing. All simulations presented in the figure are based on the respective changes of INaL parameters measured experimentally by patch-clamp (see Supplemental Material for the modeling details).
