Fig. 3.
Rate of recovery of inward INa from use-dependent block by ranolazine. A and B: recovery of INa from block induced by a train of 40 pulses in ventricular (A) and atrial (B) myocytes in the presence of 40 μM ranolazine. Insets show the last two pulses of the train with four subsequent pulses overlaid as the interpulse interval was increased. n = 6 for each cell type. C: recovery in HEK-293 cells expressing SCN5A (n = 6) after a single 1,000-ms pulse to −20 mV in the control and in the presence of 30 μM ranolazine. Dashed and solid lines are the best double-exponential fits to averaged recovery data in the control and in the presence of ranolazine, respectively. The time scale is logarithmic.