Table 2.
Experimental Values | Calculated Values | Reference | |
---|---|---|---|
Ventricular cells, 40 μM | 650 ± 170 | 820 ± 110 | |
Atrial cells, 40 μM | 707 ± 160 | 1,020 ± 110 | |
HEK-293 stable cell line expressing SCN5A, 30 μM | 660 ± 140 | 845 ± 110 | |
HEK-293 cells expressing rNav1.4-WCW, 100 μM | 560 ± 40 | 690 ± 90 | 29 |
Values are means ± SD (in ms). Rat (r)Nav1.4-WCW is the L435W/L437C/A438W mutant Na+ channel. See Table 1 for the kinetic rates of binding and unbinding at rest. HEK-293 cells, human embryonic kidney-293 cells.