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. 2011 Jun 10;301(4):H1656–H1666. doi: 10.1152/ajpheart.00141.2011

Fig. 4.

Fig. 4.

LV myocardial extracts from WT, MT1-MMPexp, and MT1-MMP+/− mice with no MI and at 14 days post-MI (n = 8/group) were subjected to gelatin zymography, which provides a measure of relative MMP-9 and MMP-2 levels. Relative MMP-9 levels were increased equivalently in the post-MI groups (data not shown). The molecular weight fractionation of the MMP-2 zymographic bands revealed a pronounced increase in the active form of MMP-2 (64 kDa) in the MT1-MMPexp groups, which was further increased post-MI. The active form of MMP-2 was reduced in the MT1-MMP+/− group post-MI. P < 0.05 vs. pre-MI values (#), vs. WT MI values (*), and vs. MT1-MMPexp MI values (+).