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. 2011 Sep 14;11:257. doi: 10.1186/1471-2148-11-257

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Copyright ©2011 Gardner et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Conservation-hydrophilicity plots and single-nucleotide changes in the hominid malaria clade in calcium-ATPase genes. (a) PfSERCA (PFA0310c) showing amino acid variants between P. falciparum and P. reichenowi and field amino acid variants (see Table 3); symbol size indicates maximum allele frequency on a countrywide basis. (b) PfATPase4 (PFL0590c), showing amino acid variants between P. falciparum and P. reichenowi as well as the mutations associated with spiroindolone selection (see text). Conservation and hydrophilicity are derived as for Figure 3.