Table 2.
DNA repair polymorphisms in the patient's pre- and post-transplantation (AML) cells and donor's cells
| Polymorphism | DNA repair mechanism | Patient cells (pre-transplantation) | AML cells (post-transplantation) | Donor cells |
|---|---|---|---|---|
| XPA A23G | NER | Homozygous for optimal DRC | Homozygous for optimal DRC | Homozygous for optimal DRC |
| XPD Lys751Gln | NER | Heterozygous deficient DRC | Homozygous for deficient DRC | Homozygous for deficient DRC |
| XRCC1 Ar399Gln | BER | Homozygous for optimal DRC | Homozygous for optimal DRC | Homozygous for optimal DRC |
| XRCC3 Thr243Met | HRR | Heterozygous for deficient DRC | Homozygous for deficient DRC | Homozygous for deficient DRC |
| RAD51 G135C | HRR | Homozygous for optimal DRC | Homozygous for optimal DRC | Homozygous for optimal DRC |
DRC - DNA repair capacity
NER - Nucleotide Excision Repair
BER - Base Excision Repair
HRR - Homologous Recombination Repair