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Regeneration versus muscle strength. There wass a significant relationship between regeneration in terms of number of neonatal myosin heavy chain (nMHC)-positive fibers as a function of ankle dorsiflexion (ADF) strength in patients with LGMD2I, reflecting greater need for muscle regeneration in patients who have lost muscle strength through muscle wasting (squares = patients homozygous for L276I; triangles = patients compound heterozygous for L276I).
