Figure 5. Conservation of mouse and human pluripotency fingerprint genes.

A. Venn diagram showing the overlap in genes that fail to reprogram expression in partial iPSCs (clusters 15 and 16 in Hiratani et al., 2010) and the mouse pluripotency fingerprint (left), between the human and mouse ESC fingerprints (middle), and the human ESC and mouse EpiSC fingerprint (right). B. Conservation (R²) of replication timing between human and mouse lymphoblasts (hLymph-mLymph), neural precursors (hNPC-mNPC) and primed stem cells (hESC-mEpiSC) as a function of developmental timing changes. For the most closely aligned samples, both relatively static and highly dynamic regions show a decreased alignment in replication timing between species.