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. 2011 Oct 20;7(10):e1002238. doi: 10.1371/journal.pcbi.1002238

Table 3. Number of clusters (NOC) at 1.15 Å RMSD cutoff for the MD simulations and experimental thermodynamic stability data for wild-type p53 and its more-stabilized forms.

NOC Thermodynamic stability (kcal/mol)
wt 21 0a
N239Y 19 −1.49b
M133L_V203A_N239Y_N268D (first 30 ns of MD simulation) 25 −2.65b
M133L_V203A_N239Y_N268D (second 30 ns of MD simulation) 9 −2.65b

aRef 23.

bRef 37. Both mutants are functionally active.