Table 1. Multivariate survival analysis.

	Overall Survival		Event-Free Survival
Risk factor	HR (95% CI)	P-value	HR (95% CI)	P-value
PTP4A3 expression	1.112 (0.995–1.243)	0.061	1.131 (1.019–1.255)	0.021*
Age (decades)	1.134 (1.024–1.256)	0.016*	1.068 (0.969–1.177)	0.186
WBC∞	1.373 (1.063–1.773)	0.015*	1.296 (1.020–1.648)	0.034*
Favorable cytogenetic risk†	0.376 (0.257–0.548)	<0.0001*	0.469 (0.335–0.658)	<0.0001*
Unfavorable cytogenetic risk†	1.432 (1.059–1.935)	0.020*	1.507 (1.124–2.020)	0.006*
NPM1+FLT3ITD-‡	0.473 (0.317–0.705)	0.0002*	0.578 (0.398–0.839)	0.004*
CEBPA double mutant$	0.591 (0.418–0.836)	0.003*	0.560 (0.384–0.815)	0.002*

Multivariate analysis in 454 de novo AML patients under the age of 60.

^∞WBC higher than 20×10⁹/L versus lower than 20×10⁹/L,

^†compared to intermediate cytogenetic risk,

^‡compared to no NPM1 ⁺ FLT3ITD ⁻,

^$compared to no CEBPA double mutation.

*Statistically significant. HR = hazard ratio, CI = confidence interval, WBC = white blood cell count, FLT3ITD = internal tandem duplication of FLT3.