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. 2011 Oct 20;7(10):e1002317. doi: 10.1371/journal.pgen.1002317

Figure 1. The computational procedure used to detect ultra-edited RNA.

Figure 1

(A) An outline of the procedure. (B) An illustration of the transformation algorithm. Top panel: an alignment between (hypothetical) ultra-edited RNA and its DNA source. A-to-G mismatches are denoted with red stars and mismatching nucleotides are highlighted in red. Bottom panel: alignment of the same sequences, but where each A was transformed to G (in both the DNA and the RNA). Transformed nucleotides are highlighted in light blue. A-to-G mismatches, but also A-A matches, become G-G matches in the transformed sequences. The transformed DNA and RNA therefore perfectly align.