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. 2011 Oct 20;6(10):e26601. doi: 10.1371/journal.pone.0026601

Figure 1. Bioinformatic prediction of microRNAs potentially targeting the CFTR gene.

Figure 1

(A) Schematic representation of the CFTR 3’UTR and miRNAs (triangles). Ribonucleotide sequences of the putative miR-101 and miR-494 responsive elements in aligned human, rhesus and mouse CFTR 3’UTRs paired with the mature human miR-sequence (from TargetScan 5.1 database). Numbers indicate the predicted miR-101 and miR-494 seed sequences (in bold) using the numbering of the human CFTR 3’UTR (3HSAR032708 from UTRdb database). (B) Predicted CFTR 3’UTR hybrid structure with miR-101 or miR-494 and mean free energy (mfe) obtained by RNAHybrid server.