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. 2011 Oct 20;7(10):e1002347. doi: 10.1371/journal.pgen.1002347

Figure 1. The timeline of putative selective events at two loci with alleles refractory to sigma virus infection.

Figure 1

At the ref(3)D locus, a selective sweep occurred between 25 and 240 years ago (indicated in green), reducing the frequency of the susceptible A allele (shown in blue) and increasing the frequency of the resistant B allele (yellow) to over 80%. The first unique features of the B allele have been dated to 90,000 years ago. The highly resistant C allele (red) is present in only one of the lines tested. At the ref(2)P locus, the GLU-ASP resistance allele is present at about 20% frequency in some contemporary populations, and is believed to have arisen 1,000–7,000 years ago.