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. 2011 Oct 20;7(10):e1002343. doi: 10.1371/journal.pgen.1002343

Table 4. Genetic terms significantly associated with variation in pathogen resistance.

Genetic term Response Dataset a Model d.f. Termb Coefficient (s.e.) p-value ΔAIC c
Il1b Tick infection CS Heterozygosity 1 Heterozygote 0.91 (0.41) 0.021 -
Bartonella infection Long. Heterozygosity 1 Heterozygote −0.61 (0.23) 0.008* 4.6
Flea infection Long. Additived 4 GGC 0.36 (0.19) 0.053* 2.2
GAT −0.22 (0.21)
AAC −0.25 (0.25)
GGT 1.27 (1.23)
Il2 Nematode infection CS Additivee 2 AG −0.03 (0.26) 0.043 -
TC 0.70 (0.29)
Cestode burden CS Heterozygosity 1 Heterozygote −0.45 (0.14) 0.001 -
Flea burden CS Heterozygosity 1 Heterozygote −0.27 (0.14) 0.049 -
Tick infection Long. Additive 2 AG 0.21 (0.19) 0.122* 2.3
TC −0.66 (0.34)
Tick burden CS Heterozygosity 1 Heterozygote 0.58 (0.28) 0.038 -
Babesia infection Long. Heterozygosity 1 Heterozygote 0.66 (0.23) 0.002* 7.2
Bartonella infection Long. Heterozygosity 1 Heterozygote −0.61 (0.21) 0.004* 5.9
Il12b Nematode infection CS Additivef 2 CC 1.42 (0.44) 0.006 -
GT 0.42 (0.75)
Babesia infection Long. Additive 2 CC 1.02 (0.31) 0.003* 6.8
GT 0.26 (0.77)
Slc11a1 Flea burden CS Heterozygosity 1 Heterozygote −0.28 (0.14) 0.046 -
Tick burden CS Heterozygosity 1 Heterozygote 0.67 (0.28) 0.015 -
Tlr2 Cestode burden CS Heterozygosity 1 Heterozygote 0.37 (0.14) 0.007 -
Tnf Cestode infection CS Additive 1 T −0.68 (0.22) 0.001 -
a

Refers to cross-sectional (CS) or longitudinal (Long.) studies, which utilized GLMs and GLMMS, respectively, for analyses (see text).

b

Under an additive model, listed haplotypes were compared against the most common haplotype at that locus; under a heterozygosity model, values of heterozygotes were compared against homozygotes (see text).

c

Increment in AIC of the model if single term is dropped (GLMMs only).

d

Also significant under a heterozygosity model (ΔAIC = 2.1).

e

Also significant under a heterozygosity model (p = 0.043).

f

Also significant under a heterozygosity model (p = 0.007).

*P-values given for analyses using GLMMs are for equivalent GLMs.