Table 4. Genetic terms significantly associated with variation in pathogen resistance.
Genetic term | Response | Dataset a | Model | d.f. | Termb | Coefficient (s.e.) | p-value | ΔAIC c |
Il1b | Tick infection | CS | Heterozygosity | 1 | Heterozygote | 0.91 (0.41) | 0.021 | - |
Bartonella infection | Long. | Heterozygosity | 1 | Heterozygote | −0.61 (0.23) | 0.008* | 4.6 | |
Flea infection | Long. | Additived | 4 | GGC | 0.36 (0.19) | 0.053* | 2.2 | |
GAT | −0.22 (0.21) | |||||||
AAC | −0.25 (0.25) | |||||||
GGT | 1.27 (1.23) | |||||||
Il2 | Nematode infection | CS | Additivee | 2 | AG | −0.03 (0.26) | 0.043 | - |
TC | 0.70 (0.29) | |||||||
Cestode burden | CS | Heterozygosity | 1 | Heterozygote | −0.45 (0.14) | 0.001 | - | |
Flea burden | CS | Heterozygosity | 1 | Heterozygote | −0.27 (0.14) | 0.049 | - | |
Tick infection | Long. | Additive | 2 | AG | 0.21 (0.19) | 0.122* | 2.3 | |
TC | −0.66 (0.34) | |||||||
Tick burden | CS | Heterozygosity | 1 | Heterozygote | 0.58 (0.28) | 0.038 | - | |
Babesia infection | Long. | Heterozygosity | 1 | Heterozygote | 0.66 (0.23) | 0.002* | 7.2 | |
Bartonella infection | Long. | Heterozygosity | 1 | Heterozygote | −0.61 (0.21) | 0.004* | 5.9 | |
Il12b | Nematode infection | CS | Additivef | 2 | CC | 1.42 (0.44) | 0.006 | - |
GT | 0.42 (0.75) | |||||||
Babesia infection | Long. | Additive | 2 | CC | 1.02 (0.31) | 0.003* | 6.8 | |
GT | 0.26 (0.77) | |||||||
Slc11a1 | Flea burden | CS | Heterozygosity | 1 | Heterozygote | −0.28 (0.14) | 0.046 | - |
Tick burden | CS | Heterozygosity | 1 | Heterozygote | 0.67 (0.28) | 0.015 | - | |
Tlr2 | Cestode burden | CS | Heterozygosity | 1 | Heterozygote | 0.37 (0.14) | 0.007 | - |
Tnf | Cestode infection | CS | Additive | 1 | T | −0.68 (0.22) | 0.001 | - |
Refers to cross-sectional (CS) or longitudinal (Long.) studies, which utilized GLMs and GLMMS, respectively, for analyses (see text).
Under an additive model, listed haplotypes were compared against the most common haplotype at that locus; under a heterozygosity model, values of heterozygotes were compared against homozygotes (see text).
Increment in AIC of the model if single term is dropped (GLMMs only).
Also significant under a heterozygosity model (ΔAIC = 2.1).
Also significant under a heterozygosity model (p = 0.043).
Also significant under a heterozygosity model (p = 0.007).
*P-values given for analyses using GLMMs are for equivalent GLMs.