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. 2011 Oct 20;7(10):e1002338. doi: 10.1371/journal.pgen.1002338

Figure 3. Genetic rescue of the bel phenotype with an Oxr1 transgene.

Figure 3

(A) In situ hybridisation of Oxr1 from littermates at P24 shows the ubiquitous expression of the Oxr1 transgene (from bel/bel Tg(Oxr1)/+ sections) in the brain. Two independent lines of bel/bel Tg(Oxr1)/+ ‘rescue’ mice display no ataxia and no apoptotic cell death in the cerebellum as shown by TUNEL staining (B) compared to control bel mice that do not express the transgene (bel/bel+/+), demonstrating that replacement of Oxr1 is sufficient to rescue the bel phenotype. Scale bars: 2 mm (A), 150 µM (B).