Table 3.
Synthesis of 15a–d.
| Product | mg 9 | mg 11 (equiv) | mg 10 (equiv) | Yield, mg (%) | MALDI-TOF |
|---|---|---|---|---|---|
| 15a | 205 | 30 (0.2) | 57 (10)a | 14 (17)a | Figure S7 |
| 15b | 17 | 25 (2) | 50 (12) | 15 (23) | nrb |
| 15c | 19 | 41 (3) | 47 (10) | 11 (13) | nrb |
| 15d | 11 | 40 (5) | 27 (10) | 15 (26) | nrb |
a
Equivalents and yield based on 40 mg (23 µmol) of purified mono-CCK4 intermediate; see Experimental Section for details.
b
MALDI-TOF spectra showed no ions that could be identified as belonging to product. Yield determined by sample weight and UV spectroscopy.