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. Author manuscript; available in PMC: 2011 Oct 20.
Published in final edited form as: Nat Rev Gastroenterol Hepatol. 2010 Oct 5;7(11):620–628. doi: 10.1038/nrgastro.2010.153

Table 5.

Biomarkers for colonic neoplasia

Disease Biomarker Category
Sporadic adenocarcinoma Stool DNA Diagnosis
KRAS gene Therapeutic Response
MLH1 Methylation Therapeutic Response
Familial adenomatouspolyposis APC gene Diagnosis
MUTYH-associated adenomatous polyposis MUTYH gene Diagnosis
Hereditary non-polyposis colorectal cancer MSI Diagnosis
MLH1, MSH2, MSH6, PMS2 genes Diagnosis
MLH1Methylation Therapeutic response