Fig. 3.
Comparison of fungal burden in the lungs (A, B) and spleen (C) of wild-type and NOX2-/- mice at days 7 and 11 postchallenge. These studies were conducted using non-vaccinated and vaccinated mice. The median CFUs (log10) are indicated by horizontal lines inside each box plot. No statistically significant differences were observed between the fungal burden in lungs and spleen of non-vaccinated WT and NOX2-/- mice at days 7 or 11 postchallenge. Both vaccinated WT and NOX2-/- mice showed reduced fungal burden in their lungs and spleen compared to the non-vaccinated mice, but no significant difference in CFUs was evident between these two mouse strains. The results are representative of two independent experiments.