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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Circ Cardiovasc Genet. 2011 Aug 12;4(5):500–509. doi: 10.1161/CIRCGENETICS.111.960633

Figure 2.

Figure 2

Peptides Containing the H558R-Polymorphism Restore Function of the R282H BrS Mutant Channel A. Whole-cell sodium current traces recorded from transfected HEK293 cells. The R282H mutation expressed alone does not generate functional sodium current. Current was restored when the mutant was co-expressed with R558-containing peptide fused with CFP (R282H+R558-40aa and R282H+R558-20aa), but not when co-expressed with the WT peptide (R282H+H558-20aa). B. Peak sodium current densities. Current density was similar for WT (n=6), R282H+R558-40aa (n=8), and R282H+R558-20aa (n=12) and significantly lower for R282H+H558-20aa (n=11). C. Current-Voltage Relationships were similar for all conditions. *P<0.05 compared to WT.