Table 1.
Electrophysiological Properties for Wild-Type and BrS Mutant hNav1.5 Channels in the Presence or Absence of the Peptide Fragments.
| Na Channels hNav1.5 |
Peak Current Density (pA/pF) |
Steady-State Inactivation (V1/2), mV |
Recovery From Inactivation (τrec), ms |
|---|---|---|---|
| WT (n=7) | −337.7 ± 105.8 | −91.9 ± 1.7 | 8.4 ± 1.0 |
| WT+R558-40aa (n=9) | −474.1 ± 125.9 | −90.0 ± 1.6 | 7.0 ± 0.7 |
| R282H (n=10) | −9.7 ± 3.0a | n.a. | n.a. |
| R282H+H558-20aa (n=12) | −9.9 ± 2.8a | n.a. | n.a. |
| R282H+R558-40aa (n=9) | −101.9 ± 21.2b | −80.6 ± 2.7a | 4.5 ± 0.4a |
| R282H+R558-20aa (n=13) | −252.9 ± 71.8b | −82.8 ± 1.5a | 5.0 ± 0.5a |
a
P<0.01 compared with wild type.
b
P<0.01 compared with mutant alone.
n.a. = not available due to the small currents.