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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Circ Cardiovasc Genet. 2011 Aug 12;4(5):500–509. doi: 10.1161/CIRCGENETICS.111.960633

Table 1.

Electrophysiological Properties for Wild-Type and BrS Mutant hNav1.5 Channels in the Presence or Absence of the Peptide Fragments.

Na Channels
hNav1.5
Peak Current
Density
(pA/pF)
Steady-State
Inactivation
(V1/2), mV
Recovery From
Inactivation
rec), ms
WT (n=7) −337.7 ± 105.8 −91.9 ± 1.7 8.4 ± 1.0
WT+R558-40aa (n=9) −474.1 ± 125.9 −90.0 ± 1.6 7.0 ± 0.7
R282H (n=10) −9.7 ± 3.0a n.a. n.a.
R282H+H558-20aa (n=12) −9.9 ± 2.8a n.a. n.a.
R282H+R558-40aa (n=9) −101.9 ± 21.2b −80.6 ± 2.7a 4.5 ± 0.4a
R282H+R558-20aa (n=13) −252.9 ± 71.8b −82.8 ± 1.5a 5.0 ± 0.5a
a

P<0.01 compared with wild type.

b

P<0.01 compared with mutant alone.

n.a. = not available due to the small currents.