. Author manuscript; available in PMC: 2012 Nov 1.

Published in final edited form as: Genet Epidemiol. 2011 Sep 15;35(7):581–591. doi: 10.1002/gepi.20603

Table 2. Test Power^a in Meta-analysis of Three Case-control Studies (α = 10^-8).

Study-site	1	2	3	Summary Test Statistic

Cases	500	1000	500		Score-based			Wald-based
Controls	500	1000	5000	Z_HM^b	Z_HT^c	Z_SZ^d	Z_HM	Z_HT	Z_SZ
Odds-ratio MAF	1.3	1.3	1.3
	0.2	0.2	0.2	0.356	0.349	0.301	0.348	0.343	0.291
	0.3	0.3	0.3	0.638	0.632	0.563	0.634	0.629	0.555
	0.3	0.3	0.2	0.543	0.537	0.426	0.530	0.527	0.418

Odds-ratio MAF	1.4	1.4	1.4
	0.2	0.2	0.2	0.887	0.886	0.840	0.886	0.885	0.836
	0.3	0.3	0.3	0.974	0.974	0.951	0.974	0.974	0.949
	0.3	0.3	0.2	0.953	0.950	0.908	0.951	0.950	0.904

Odds-ratio MAF	1.0	1.4	1.3
	0.2	0.2	0.2	0.188	0.086	0.170	0.185	0.086	0.164
	0.3	0.3	0.3	0.457	0.230	0.420	0.452	0.221	0.409
	0.3	0.3	0.2	0.323	0.168	0.260	0.309	0.166	0.254

^a)

fraction of 1000 replications rejecting H₀ at α = 10^-8

^b)

homogeneity weights of equation (17)

^c)

heterogeneity weights of equation (19)

^d)

weights proportional to square root of study size

Table 2. Test Powera in Meta-analysis of Three Case-control Studies (α = 10-8).