. Author manuscript; available in PMC: 2012 Nov 1.

Published in final edited form as: Genet Epidemiol. 2011 Sep 15;35(7):581–591. doi: 10.1002/gepi.20603

Table 4. Test Power^a in Meta-analysis of Six Survival Studies.

Associated SNP	MAF	Log hazard ratio β	Summary Test Statistic

			Score-based			Wald-based
			Z_HM^b	Z_HT^c	Z_SZ^d	Z_HM	Z_HT	Z_SZ
rs17360123	0.2	0.25	0.264	0.202	0.172	0.265	0.208	0.162
		0.30	0.530	0.449	0.416	0.550	0.487	0.403
		0.35	0.827	0.709	0.716	0.841	0.792	0.709
		Heterogeneous β^e	0.294	0.117	0.201	0.302	0.129	0.194
rs4012375	0.4	0.25	0.463	0.422	0.333	0.465	0.429	0.318
		0.30	0.787	0.719	0.673	0.787	0.738	0.665
		0.35	0.954	0.884	0.910	0.956	0.904	0.907
		Heterogeneous β^e	0.566	0.204	0.416	0.579	0.232	0.401

^a)

fraction of 1000 replications in rejecting H₀ at α = 10^-5

^b)

homogeneity weights of equation (17)

^c)

heterogeneity weights of equation (19)

^d)

weights proportional to square root of study size

^e)

β = 0 for sites 1,2, and β = 0.35 for studies 3-6

Table 4. Test Powera in Meta-analysis of Six Survival Studies.