Table 2.
Pedigree Disequilibrium Tests of association for individual SNPs and three alcohol dependence phenotypes.
| p-values | ||||
|---|---|---|---|---|
| SNP | Gene | Alcohol Dependence Diagnosis |
Experienced Withdrawal Symptoms |
Experienced Severe Symptoms |
| rs1230155 | ADH5 | 0.7561 | 0.9254 | 0.2974 |
| rs7683802 | ADH5 | 0.5527 | 0.3642 | 0.8073 |
| rs4699699 | ADH5 | 0.5560 | 0.3206 | 0.8734 |
| rs4699700 | ADH5 | 0.4647 | 0.2767 | 0.5125 |
| rs1154412 | ADH5 | 0.4147 | 0.4171 | 0.0285 |
| rs7683704 | ADH5 | 0.5539 | 0.2733 | 0.6551 |
| rs1154401 | ADH5 | 0.8639 | 0.8597 | 0.3020 |
| rs1154400 | ADH5 | 0.6093 | 0.8938 | 0.4862 |
| rs7667261 | ADH5 | 0.6547 | 0.7970 | 0.4071 |
| rs2602846* | ADH5/ADH4 | 0.9198 | 0.8234 | 0.2365 |
| rs2602866 | ADH5/ADH4 | 0.5191 | 0.9668 | 0.2510 |
| rs1042365* | ADH4 | 0.9770 | 0.7640 | 0.5993 |
| rs1042364* | ADH4 | 0.9975 | 0.6163 | 0.4294 |
| rs29001229 (DWSHpy188I)* |
ADH4 | 0.8111 | 0.9402 | 0.4591 |
| rs1126672* | ADH4 | 0.9336 | 0.9973 | 0.1815 |
| rs1126671 | ADH4 | 0.5827 | 0.9056 | 0.1670 |
| rs1126670 | ADH4 | 0.5911 | 0.8728 | 0.1592 |
| rs7694646* | ADH4 | 0.8928 | 0.9365 | 0.3564 |
| rs4699714* | ADH4 | 0.7175 | 0.6134 | 0.4137 |
| rs4148886 | ADH4 | 0.1427 | 0.5866 | 0.0266 |
| rs1800759* | ADH4 | 0.7167 | 0.1312 | 0.3405 |
| rs3762894* | ADH4 | 0.1596 | 0.0012 | 0.9496 |
| rs4699718* | ADH4/ADH6 | 0.9005 | 0.8942 | 0.2098 |
| rs1984362* | ADH4/ADH6 | 0.8366 | 0.8358 | 0.3232 |
| rs4147545 | ADH6 | 0.2857 | 0.6914 | 0.0615 |
| rs3857224 | ADH6 | 0.1595 | 0.3529 | 0.0663 |
| rs6833176 | ADH6 | 0.0487 | 0.3893 | 0.1185 |
| rs9307238 | ADH6 | 0.0950 | 0.5078 | 0.1592 |
| rs1230026 | ADH6/ADH1A | 0.8477 | 0.6762 | 0.5316 |
| rs1618572 | ADH6/ADH1A | 0.8908 | 0.7292 | 0.5229 |
| rs2866151* | ADH1A | 0.5055 | 0.2234 | 0.7288 |
| rs3819197 | ADH1A | 0.3042 | 0.0396 | 0.7143 |
| rs1229976 | ADH1A | 0.9635 | 0.7384 | 0.4354 |
| rs1229970 | ADH1A | 0.9563 | 0.6809 | 0.6310 |
| rs6828526 | ADH1A | 1.0000 | 1.0000 | 1.0000 |
| rs1229967 | ADH1A | 0.8321 | 0.7754 | 0.3722 |
| rs3805325 | ADH1A | 0.1138 | 0.5002 | 0.3048 |
| rs4147531* | ADH1A | 0.2741 | 0.1124 | 0.7801 |
| rs1229966 | ADH1A | 0.4680 | 0.7293 | 0.2949 |
| rs1826909* | ADH1A/1B | 0.6383 | 0.2966 | 0.3797 |
| rs1042026 | ADH1B | 0.5340 | 0.1445 | 0.6680 |
| rs2066702* | ADH1B | 0.6446 | 0.0018 | 0.0717 |
| rs1789883 | ADH1B | 0.5377 | 0.1878 | 0.3544 |
| rs2066701 | ADH1B | 0.4972 | 0.1383 | 0.6085 |
| rs1229984* | ADH1B | 0.1177 | 0.2561 | 0.5283 |
| rs1229983 | ADH1B | 0.8007 | 0.1807 | 0.1709 |
| rs1353621 | ADH1B | 0.7413 | 0.3749 | 0.4154 |
| rs1159918* | ADH1B | 0.6215 | 0.9254 | 0.5548 |
| rs1229982* | ADH1B | 0.8587 | 0.7335 | 0.1824 |
| rs1614972 | ADH1C | 0.6216 | 0.4558 | 0.6042 |
| rs35719513 (P351T) |
ADH1C | 0.7438 | 0.1446 | 0.3611 |
| rs698* | ADH1C | 0.8423 | 0.0344 | 0.2718 |
| rs1789903 | ADH1C | 0.8085 | 0.3926 | 0.0389 |
| rs1693482* | ADH1C | 0.8101 | 0.0668 | 0.2606 |
| rs1693426 | ADH1C | 0.8665 | 0.3960 | 0.0590 |
| rs1789915 | ADH1C | 0.9266 | 0.0964 | 0.6475 |
| rs3133158 | ADH1C | 0.9713 | 0.1166 | 0.5221 |
| rs1789924 | ADH1C | 0.8435 | 0.4608 | 0.0679 |
| rs1229849 | ADH1C/ADH7 | 0.9401 | 0.1347 | 0.6898 |
| rs283406 | ADH1C/ADH7 | 0.2419 | 0.8143 | 0.9149 |
| rs284794 | ADH1C/ADH7 | 0.9504 | 0.8343 | 0.7660 |
| rs284786* | ADH7 | 0.9911 | 0.4685 | 0.9435 |
| rs284779* | ADH7 | 0.3723 | 0.1719 | 0.6271 |
| rs2584464 | ADH7 | 0.4379 | 0.3188 | 0.6852 |
| rs971074 | ADH7 | 0.8276 | 0.9676 | 0.1473 |
| rs1154468 | ADH7 | 0.5625 | 0.3428 | 0.6853 |
| SBP2 | ADH7 | 0.4194 | 0.2265 | 0.7587 |
| rs1154476 | ADH7 | 0.3853 | 0.2905 | 0.5450 |
| rs894363 | ADH7 | 0.4638 | 0.3110 | 0.3960 |
Notes:
*
Indicates SNPs that were genotyped in the full sample, italicized text indicates p-value<0.05, bold text indicates p-value<0.002.