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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Circ Cardiovasc Genet. 2011 Aug 31;4(5):549–556. doi: 10.1161/CIRCGENETICS.111.960393

Figure 1.

Figure 1

Conceptual framework for the integration of GWA data with protein-protein interaction data. The approach consists of three overall steps. First, GWA meta-analysis, SNPs are mapped to genes, genes are scored based on its most significant SNP, and the gene scores are adjusted by the number of independent SNPs mapped to the given gene. Second, protein complexes are assembled based on experimentally derived protein-protein interactions. Finally, the gene-sets underlying the protein complexes are scored based on their genes’ p-values and their protein-protein interaction confidence scores.