Table 2.

Genes and primary SNPs in the top-ranking protein complex based on the GWA meta-analysis of risk of CHD in the Nurses’ Health and Health Professionals Follow-Up Studies.

Gene	Gene p-value*	Top SNP	MAF	OR	Top SNP, raw p-value	# SNPs in gene	# independent SNPs in gene
MAGI1	7.8E-04	rs7620106	0.40	1.30	9.1E-06	251	86
PRKACA	0.004	rs40282	0.46	1.20	0.002	2	2
GOPC	0.028	rs12664183	0.28	1.23	0.001	100	27
ADRB1	0.041	rs17653278	0.06	0.70	0.003	41	12
MAGI3	0.073	rs4839312	0.26	1.21	0.005	62	14
MAGI2	0.086	rs2065198	0.46	1.22	0.001	579	149
GRB2	0.107	rs7223674	0.05	0.72	0.014	32	8
DLGAP2	0.143	rs7836020	0.45	1.18	0.005	100	33
ARRB1	0.217	rs2279129	0.08	0.75	0.013	34	19
DLG4	0.251	rs5412	0.16	1.15	0.069	7	4
GNAL	0.277	rs2848465	0.22	0.83	0.009	85	36
GIPC1	0.304	rs4926215	0.47	0.89	0.042	15	8
DLG1	0.335	rs7616531	0.26	1.17	0.020	56	20
GPRASP1	0.348	rs17340189	0.11	1.15	0.090	6	5
ADRA2A	0.355	rs7908645	0.34	1.13	0.056	15	8
SH3GL3	0.441	rs8025427	0.42	1.15	0.018	68	31
GNAS	0.508	rs1022697	0.43	1.13	0.032	50	21
SH3GL2	0.562	rs10810813	0.16	0.83	0.019	162	43
PDE4D	0.677	rs17799450	0.08	1.34	0.015	312	74

^*adjusted for the number of independent SNP within loci (see last column, independent SNPs in gene). Full gene names available in online supplement.