Figure 6. Pharmacological activation of the CB1 receptor within distinct amygdalar nuclei differentially affects stress-induced increases in corticosterone secretion.
Infusion of the CB1 receptor agonist HU-210 (2.5 μg) into the basolateral amygdala (BLA) suppressed stress-induced corticosterone secretion, in a CB1 receptor-dependent manner, while infusion of HU-210 into the medial amygdala (MeA) enhanced stress-induced corticosterone secretion. There was no effect of HU-210 infusion into the central nucleus of the amygdala (CeA). Values denoted are means ± SEM. * denotes significant differences (p < .05).