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. Author manuscript; available in PMC: 2011 Oct 21.
Published in final edited form as: Expert Opin Ther Targets. 2009 Oct;13(10):1227–1238. doi: 10.1517/14728220903190707

Table 1.

Mammalian miRNAs regulating adipogenesis and insulin sensitivity.

miRNA Function Model system Targets References
miR-143 Pro-adipogenic Primary human preadipocytes, 3T3-L1 ERK5/MAPK7(?) 33, 37
miR-103 Pro-adipogenic 3T3-L1 33
miR-200 Pro-adipogenic ST2 47
miR-17–92 cluster Pro-adipogenic 3T3-L1 Rb2/p130 38
Let-7 Anti-adipogenic 3T3-L1 Hmga2 40
miR-27 Anti-adipogenic 3T3-L1, OP9 39
miR-29 Inhibitor of glucose uptake 3T3-L1 Insig1(?), Cav2(?) 52

3T3-L1, mouse preadipocyte cell line; ST2 and OP9, mouse bone marrow stromal cells

?

Validated targets but their participation in adipogeneis or insulin signaling pathway is not clear