Table 1.
miRNA | Function | Model system | Targets | References |
---|---|---|---|---|
miR-143 | Pro-adipogenic | Primary human preadipocytes, 3T3-L1 | ERK5/MAPK7(?) | 33, 37 |
miR-103 | Pro-adipogenic | 3T3-L1 | 33 | |
miR-200 | Pro-adipogenic | ST2 | 47 | |
miR-17–92 cluster | Pro-adipogenic | 3T3-L1 | Rb2/p130 | 38 |
Let-7 | Anti-adipogenic | 3T3-L1 | Hmga2 | 40 |
miR-27 | Anti-adipogenic | 3T3-L1, OP9 | 39 | |
miR-29 | Inhibitor of glucose uptake | 3T3-L1 | Insig1(?), Cav2(?) | 52 |
3T3-L1, mouse preadipocyte cell line; ST2 and OP9, mouse bone marrow stromal cells
Validated targets but their participation in adipogeneis or insulin signaling pathway is not clear