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. Author manuscript; available in PMC: 2011 Oct 21.
Published in final edited form as: Future Oncol. 2010 Apr;6(4):551–562. doi: 10.2217/fon.10.11

Figure 1. Fatty acid biosynthesis in malignancy.

Figure 1

Glucose is taken up into cells and is converted into pyruvate via anaerobic glycolysis. Pyruvate in turn is converted into citrate in the mitochondria via Krebs cycle to generate ATP. Excess citrate is metabolized to acetyl-CoA, which enters the lipogenesis pathway, ultimately leading to production of long-chain acyl-CoA.

ACACA: Acetyl co-enzyme A carboxylase; ACLY: ATP citrate lyase; ACS: Acyl co-enzyme A synthetase; CoA: Co-enzyme A; FASN: Fatty acid synthase; NADPH: Nicotinamide adenine dinucleotide phosphate.