Skip to main content
. Author manuscript; available in PMC: 2011 Oct 21.
Published in final edited form as: Future Oncol. 2010 Apr;6(4):551–562. doi: 10.2217/fon.10.11

Figure 2. Regulation of fatty acid synthase expression in malignancy.

Figure 2

Once growth factor or steroid hormone receptors are activated by their corresponding ligand this leads to downstream activation of the PI3K/AKT or MAPK pathways. Both transduction pathways regulate FASN expression through modulation of expression of SREBP-1c and FBI-1, which binds to regulatory elements in the FASN promoter.

FASN: Fatty acid synthase; FBI-1: Pokemon; GF: Growth factor; GFR: Growth factor receptor; SR: Steroid Hormone receptor; SREBP-1c: Sterol regulatory element-binding protein 1c.