Skip to main content
. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Dev Dyn. 2011 Sep 26;240(11):2474–2481. doi: 10.1002/dvdy.22750

Fig. 6. Proposed Model.

Fig. 6

A: In normal development, TAK1 binds to HGS, ensuring its localization in the early endosome. HGS probably acts as a scaffold to facilitate both phosphorylation of SMADs and autophosphorylation of TAK1 to transduce non-SMAD BMP signaling. B: In Hgs−/−embryos, TAK1 is not localized in the early endosome, thus BMP signaling mediated by TAK1 and subsequent MAK kinase cascades are largely compromised. The canonical BMP signaling mediated by phosphorylation of SMADs is less affected probably due to compensation by other molecules.