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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: J Immunol. 2011 Sep 26;187(9):4629–4638. doi: 10.4049/jimmunol.1004076

Figure 6. Combination of sCTLA4-Ig and anti-Delta1 lowered GrB and IFN-γ production, while it increased Th2 cytokines.

Figure 6

(A) Donor specific cytokine production of splenocytes from B6 WT recipients of BALB/c allografts were assessed 14 days after transplantation by ELISPOT and Luminex assay. GrB (B), IL-2, IFN-γ and IL-6 was significantly decreased in the combined sCTLA4-Ig /anti-Delta1 group, while Th2 cytokines (IL-4, IL-5 and IL-13) were increased when compared to sCTLA4-Ig alone group. Data are representative of 3 independent experiments and indicate the mean of triplicate results in each experiment. (* p<0.05).