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. Author manuscript; available in PMC: 2012 Oct 27.
Published in final edited form as: J Med Chem. 2011 Sep 30;54(20):7280–7288. doi: 10.1021/jm200855b

Figure 5.

Figure 5

Compounds 3 reduced immobility in the forced swim test in mice when given orally at 10 mg/kg. Immobility was slightly higher at the lowest dose. Compound 5 was efficacious at all doses tested. The SSRI sertraline, produced the expected decrease in immobility. (ANOVAs: Fs > 34.5; ps < 0.001. *Fisher’s PLSD post-hoc tests: ps < 0.05 vs vehicle). N = 9−10/group.