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. Author manuscript; available in PMC: 2012 Oct 27.
Published in final edited form as: J Med Chem. 2011 Sep 30;54(20):7280–7288. doi: 10.1021/jm200855b

Scheme 1.

Scheme 1

a Reagents and conditions: (a) ethynyltrimethylsilane, CuI, PPh3, PdCl2 (PPh3)2, Et3N; (b) (n-Bu)4NF, THF; (c) NaH, TBSCl, THF; (d) PPh3, imidazole, I2, Et2O/MeCN; (e) AgNO2, Et2O; (f) PhNCO, Et3N, toluene; (g) HCl, ether/MeOH.