FIG. 2.

Initial ovotoxic index (OI) species comparison after 15 days in mice and rats. The dose of each chemical found to cause 50% loss of primordial follicles (A), primary follicles (B), or secondary follicles (ED50; C) in B6C3F1 mice (open bars) and Fischer 344 rats (closed bars) after 15 daily doses was used to calculate the initial OI. The initial OI is expressed as a reciprocal (1/OI) to illustrate the dramatic differences in ovotoxicity between chemicals. Thus, the higher the value, the more ovotoxic the chemical. Note: log scale. OI = (ED₅₀) × (15 days of dosing). ns, not significant (not susceptible at the experimental doses, P < 0.05). Reproduced from Borman et al. [112] with permission from Elsevier.