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. 2011 Jul 20;85(5):987–995. doi: 10.1095/biolreprod.111.093492

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© 2011 by the Society for the Study of Reproduction, Inc.

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FIG. 2. — Estradiol alters inactivation of I_A. All data are means ± SEM. A) I_A inactivation (as normalized current) is shown as a function of command potential. B) Summary bar graphs show the effects of estradiol and time of day on subtracted I_A current density following −100 mV prepulse (left) and I_K current density following −40 mV prepulse (right) in GnRH neurons from OVX mice (morning, n = 11; evening, n = 11) and OVX+E mice (morning, n = 13; evening, n = 8) during morning hours (white bars) and evening hours (black bars). **P < 0.005; *P < 0.05. The test pulse was set at −10 mV. Significant differences in inactivation at −40 mV are observed between OVX evening and OVX+E evening and between OVX+E morning and OVX+E evening; these are not indicated in A for clarity (both, P < 0.05).