Figure 3. Measurement of Percent Effective Filtration Length (PEFL).
A: The average PEFL (D) was 3.4-fold larger in both washout eyes (83.4±2.1%) and Y27 treated eyes (82.5±1.6%) compared to control eyes (24.2±4.2%, P<0.001).
B: In control eyes, a significant difference of PEFL was found between the nasal (32.2±3.7%) and temporal quadrants (16.9±3.8% p=0.007) and between the nasal and inferior quadrants (21.0±3.1% p=0.026); but no significant difference between nasal and superior quadrants (26.8±5.5%, p=0.43). After Y27 treatment, the PEFL increased in all quadrants (nasal: 81.0±2.4%, temporal: 81.1±3.7%, superior: 81.9±3.6%, inferior: 82.8±5.2%) with no significant difference between quadrants. In long perfused eyes (washout), the PEFL increased in all quadrants (nasal: 81.9±7.9%, temporal: 79.3±7.1%, superior: 83.4±3.5%, inferior: 85.9±3.3%) with no significant difference between quadrants.