Figure 6.
Representative samples from aortic tissue obtained from non-aneurysmal aorta (A and C) and aneurysmal aorta (B and D). Immunohistochemical analysis failed to show any staining for STAT1 in non-aneurysmal tissue (A (40x) and C (100x)), but was present (arrow) in the adventitial layer in samples from aortic aneurysms (B, 40x). This appeared to localize to inflammatory cells (arrows) within the adventitial layer (D, 100x). Corresponding cells in this layer also stained positive for CD68 (E, 100x) suggesting they are of a monocyte/macrophage lineage.