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An HPV-related oropharyngeal squamous cell carcinoma. Cytologic specimens were sent for hybrid capture 2 testing after the presence of tumor was confirmed by a Diff Quick stain (A). Tumor in the corresponding tissue sections (B) was determined to be HPV positive on the basis of strong p16 immunohistochemical staining (C) and the presence of in situ hybridization signals within the tumor nuclei (D).
