Table 1.

Correlation of hybrid capture 2 classification with tumor origin and HPV status by p16 immunohistochemistry and high risk HPV in-situ hybridization

Patient	tumor origin	sample site	p16 IHC	HPV ISH	Hybrid capture 2 (score)
1	tonsil	tonsil	positive	positive	positive (18.12)
2	tonsil	tonsil lymph node	positive positive	positive positive	positive (858.16) positive (1993.00)
3	tonsil	lymph node	positive	positive	positive (709.16)
4	tonsil	lung	positive	positive	positive (786.68)
5	tonsil	lymph node	positive	positive	positive (6.24)
6	tonsil	tonsil	positive	positive	positive (45.78)
7	tonsil	tonsil lymph node	positive positive	positive positive	positive(710.91) positive (1789.52)
8	tonsil	tonsil	positive	positive	positive (1781.85)
9	tongue base	tongue base	positive	positive	positive (3.21)
10	tongue base	lymph node	positive	positive	positive (210.09)
11	tongue base	tongue base	positive	positive	positive (3.47)
12	tongue base	lung	positive	negative	positive (5.45)
13	tongue base	tongue base	positive	positive	positive (26.26)
14	maxillary sinus	maxillary	positive	positive	positive (1860.52)
15	oral tongue	lymph node	negative	negative	negative (0.08)
16	oral tongue	oral tongue	negative	negative	negative (0.12)
17	floor of mouth	lymph node	negative	negative	negative (0.17)
18	gingiva gingiva	gingiva lymph node	negative negative	negative negative	negative (0.10) negative (0.11)
19	tonsil	tonsil	negative	negative	negative (0.14)
20	larynx	lymph node	negative	negative	negative (0.12)
21	larynx	lymph node	negative	negative	negative (0.11)
22	skin	lymph node	negative	negative	negative (0.16)
23	skin	lymph node	negative	negative	negative (0.12)
24	unknown	lymph node	negative	negative	negative (0.11)
Control		tonsil	not done	not done	negative (0.15)
Control		tonsil	not done	not done	negative (0.13)
Control		tonsil	not done	not done	negative (0.14)
Control		tonsil	not done	not done	negative (0.10)
Control		lymph node	not done	not done	negative (0.29)
Control		lymph node	not done	not done	negative (0.11)