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Proposed algorithm for the management of hepatitis B virus-infected patients requiring biologic therapy. HBV: Hepatitis B virus; TNF-α: Tumor necrosis factor α; HbsAg: HBV surface antigen; HBcAb: Hepatitis B core antibody; HBsAb: Hepatitis B surface antibody; ALT: Alanine transaminase; AST: Aspartate transaminase.
