Table 1.

Systemic mastocytosis findings related to mast cell infiltration and proliferation (modified from Valent et al[3])

B symptoms (Borderline benign-be watchful)

Hepatomegaly

Splenomegaly

Lymphadenopathy

Hypercellular marrow

Mast cell infiltration in bone marrow > 30%

Serum tryptase levels > 200 ng/mL

C symptoms (Consider cytoreductive therapy)

Anemia (Hb < 10 g/dL)

Thrombocytopenia (< 100 000/mm3)

Neutropenia

Hepatopathy with ascites or portal hypertension

Splenomegaly with hypersplenism

Malabsorption with weight loss

Osteolysis with pathological bone fractures