TABLE 1.
Treg depletion aggravates insulin resistance
| Minutes |
|||||||
|---|---|---|---|---|---|---|---|
| 0 | 15 | 30 | 45 | 60 | 75 | 90 | |
| Control | 0/8 | 4/8 | 3/8 | 2/8 | 1/8 | 1/8 | 1/8 |
| Treg depleted | 2/8 | 8/8 | 6/8 | 5/8 | 6/8* | 7/8* | 7/8* |
Db/db mice were uninephrectomized at the age of 6 weeks and followed for 56 days. One group received an anti-CD25 antibody intraperitoneally starting the day of and 4 weeks after uninephrectomy (n = 8). Control animals received an isotype control antibody (n = 8). Insulin-sensitivity testing was performed on day 56. The number of mice with blood glucose levels >600 mg/dL at the indicated time points are shown. Pooled data of two independent experiments are shown.
*P < 0.05 as evaluated by Fisher exact test.