TABLE 1.
Association results for rs601338G>A (W143X) in the type 1 diabetes case-control and family collections
| Case subjects | Control subjects | OR (95% CI) | P values | |
|---|---|---|---|---|
| Genotype model | 2.94x10−13 | |||
| GG | 1,849 (22.2) | 2,435 (24.3) | 1.00 (ref) | |
| AG | 3,943 (47.3) | 4,978 (49.7) | 1.05 (0.97–1.45) | |
| AA | 2,552 (30.6) | 2,595 (25.9) | 1.33 (1.29–1.73) | |
| Recessive model | 7.28x10−14 | |||
| GG,GA | 5,792 (69.4) | 7,413 (74.1) | 1.00 (ref) | |
| AA | 2,552 (30.6) | 2,595 (25.9) | 1.29 (1.20–1.37) | |
| Affected offspring | Parents | RR (95% CI) | ||
| Genotype model | 2.72x10−5 | |||
| GG | 1,414 (27.4) | 1,989 (29.6) | 1.00 (ref) | |
| AG | 2,447 (47.5) | 3,165 (47.1) | 1.04 (0.95–1.13) | |
| AA | 1,295 (25.1) | 1,566 (23.3) | 1.26 (1.12–1.40) | |
| Recessive model | 6.81x10−6 | |||
| GG,GA | 3,861 (74.9) | 5,154 (76.7) | 1.00 (ref) | |
| AA | 1,295 (25.1) | 1,566 (23.3) | 1.22 (1.12–1.32) |
Data are n (%) unless otherwise indicated. CI, confidence interval; OR, odds ratio; ref, reference genotype; RR, relative risk. The recessive model was found to be an appropriate approximation in both datasets (case-control P = 0.19 and family P = 0.35, for rejection of the recessive effects model).