FIG. 3.

β-Cell function is unaltered after α-cell ablation. A: Pancreatic insulin content measured 1 week after DT. Consistent with the specificity of α-cell ablation, pancreatic insulin content was unaffected after DT (control: 131.1 ± 5.8, n = 6; DT: 134.0 ± 11.0 ng/mg of pancreas, n = 7). B: Glucose tolerance test. DT-treated Glucagon-DTR mice (red ▲) were not intolerant to glucose 1 week after massive α-cell ablation (n = 6 for each group; control, black ♦). C: Insulin secretion measured from perfused pancreas after glucose stimulation. No significant change in insulin secretion was observed 1 week after α-cell ablation (n = 4 for each group).