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. 2011 Oct 17;60(11):2985–2994. doi: 10.2337/db10-1333

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 6. — MMP activities and TIMP expression in diabetic hearts. MMP activities were determined in Capn4^−/−, Tg-CAST, and OVE26 hearts. A: MMP activities were increased in diabetic hearts. Overexpression of calpastatin reduced total MMP activities and MMP-2 and MMP-9 activities in diabetic Tg-CAST hearts (A–C). D–F: Deficiency of Capn4 reduced total MMP activities and MMP-2 and MMP-9 activities in Capn4^−/− (knockout [KO]) relative to nondiabetic wild-type (WT) hearts. G: Total MMP activities were elevated in OVE26 relative to WT hearts and were decreased in Tg-CAST/OVE26 hearts. H and I: TIMP-1 and TIMP-2 mRNA levels were decreased in Capn4^−/− (KO) relative to nondiabetic WT hearts. Data are mean ± SD; n = 6–8. *P < 0.05 vs. WT; #P < 0.05 vs. STZ-treated WT or OVE26.