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. 2011 Oct 17;60(11):2985–2994. doi: 10.2337/db10-1333

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 8. — Cardiac function. Tg-CAST, Capn4^−/− (knockout [KO]), and wild-type (WT) mice were injected with STZ. Two (Tg-CAST) or five months (Capn4^−/−) after STZ injection, in vivo hemodynamic measurement was performed. Changes in −dP/dt_min (A and C) and LV stiffness (B and D) are shown. Data are mean ± SD; n = 6–10 per group. *P < 0.05 vs. WT sham; #P < 0.05 vs. WT STZ. Two months after STZ injection, mouse hearts were isolated and perfused in a Langendorff system. Contractile function of the heart was determined. Changes in the rate of contraction (+dF/dt_max; E and G) and relaxation (−dF/dt_min; F and H) are presented. Data are mean ± SD; n = 8 to 9 per group. *P < 0.05 vs. WT sham; #P < 0.05 vs. WT STZ.