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. 2011 Oct 17;60(11):2922–2927. doi: 10.2337/db11-0220

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — Comparison of the incidence and time of onset of type 1 diabetes in wild-type NOD/ShiLtJ and NOD/ShiLtJ G6pc2^−/− mice: the effect of sex. The incidence and time of onset of type 1 diabetes in male and female wild-type NOD/ShiLtJ, NOD/ShiLtJ G6pc2^−/+, and NOD/ShiLtJ G6pc2^−/− mice was compared starting at the age of 10 weeks. Clear differences were observed between male and female wild-type NOD/ShiLtJ mice (A), between male and female NOD/ShiLtJ G6pc2^−/− mice (B), and between male and female NOD/ShiLtJ G6pc2^−/+ mice (C). The number of animals studied is indicated in parentheses. Statistical significance between curves was determined by the log-rank (Mantel-Cox) test. Het, heterozygous; KO, knockout; WT, wild-type.