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. 2011 Oct 17;60(11):2922–2927. doi: 10.2337/db11-0220

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 3. — Insulitis in normoglycemic wild-type and G6pc2-deficient NOD/ShiLtJ mice. Paraffin sections of pancreata removed from 25-week-old normoglycemic male animals were stained by immunoperoxidase methods for the presence of insulin (gray) and glucagon (brown). Varying degrees of peri-islet mononuclear cell infiltration were evident, as visualized by the methyl green counter stain. Representative images (scale bar = 50 μm) are shown in A, whereas insulitis scores from five wild-type and five NOD/ShiLtJ G6pc2^−/− mice are shown in B, based on the examination of a total of 127 wild-type and 151 G6pc2^−/− islets. KO, knockout; WT, wild-type. (A high-quality digital representation of this figure is available in the online issue.)