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. 2011 Oct 17;60(11):2914–2921. doi: 10.2337/db11-0705

FIG. 4.

FIG. 4.

B cells entering pancreatic islets in NOD mice become CD20-negative plasma cells. A: Proportion of total B cells in pancreatic islet–associated leukocytes from 7- or 13-week-old untreated NOD female mice. B: Proportion of total B cells in pancreatic islet–associated leukocytes from 7- or 13-week-old NOD female mice treated 2 weeks earlier with anti-CD20. Noted statistical significance values in A and B were determined by ANOVA analyses. C: Pancreatic islet–infiltrating B cells in 13-week-old untreated NOD control mice acquire a CD20-negative phenotype (right panel). B cells in PLNs were assessed as a CD20-staining positive control (left panel). Flow cytometric profiles are shown for B220 gated cells. D: CD20-negative pancreatic islet–associated B cells in untreated NOD mice convert to a CD138-positive plasma cell phenotype (right panel). B cells in PLNs were analyzed as a control (left panel). Flow cytometric profiles are shown for B220 gated cells.